Agranulocytosis Due to "Iodolysin"

Reversible agranulocytosis due to meprobamate.

A 52 year old man admitted to hospital in a toxic state, was found to have agranulocytosis, which recovered when an analgesic containing meprobamate was stopped. The patient was known to have had similar symptoms 9 months previously when the drug was first used, thereby demonstrating an idiosyncratic reaction to meprobamate.

Fatal agranulocytosis due to phenylindanedione: report of a case.

PHENYLINDANEDIONE is one of several oral anticoagulants in wide use at the present time. It is generally considered to be non-toxic, but adverse reactions to the drug have been reported. We have been able to find six instances of agranulocytosis, two of jaundice,' and six of rash without fever 13 in the world literature. One of the instances of agranulocytosis was fatal. The purpose of this com...

Agranulocytosis

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.

Case report Agranulocytosis secondary to propylthiouracil

A 36-year-old Caucasian female presented with sore throat, malaise and fever for 5 days. She was febrile and physical examination was remarkable for moderate pharyngeal erythema and mild tonsil hypertrophy. A complete blood count (CBC) showed a white blood cell (WBC) count of 810/ml [87% lymphocytes, 8% variant lymphocytes, 5% monocytes and an absolute neutrophil count (ANC) of zero], hemoglobi...